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At the request of the European Medical Agency, the SCOUT (Sibutramine Cardiovascular OUTcome Trial) study was undertaken to provide post-marketing assurance of cardiovascular safety for use of the drug in high-risk individuals

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PTSD-diagnosed South African individuals showed higher levels of Mitsuokella, Odoribacter, Olsenella , and Catenibacterium compared to controls, positively correlating with childhood trauma severity

That uncertainty is precisely why it remains an interesting research tool rather than a settled one, and it is stated plainly here rather than papered over with confident mechanism claims

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