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The NF-B pathway is a pivotal transcription factor that controls the expression of numerous genes involved in immune and inflammatory responses, including cytokines like TNF- , IL-1, and IL-6

Like other copper-binding tripeptides, its biological effects are proposed to occur through both the peptide backbone and the copper ion it coordinates with the copper contributing to enzymatic cofactor activity and oxidative stress modulation

Future studies should clarify the role of immune priming in modulating behavioral responses to antibiotic-induced gutbrain effects

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Furthermore, the Philippines Food and Drug Administration (FDA) has sanctioned its application as an adjunctive treatment to mitigate the neurotoxic effects of cisplatin chemotherapy[3]

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