At 10 nmol/l Ex-4 inhibits IB-phosphorylation and prevents NF-B/p65 nuclear translocation, halving tumor necrosis factor alpha (TNF-) and IL-6 both intracellularly and in the medium [19], thereby attenuating pro-inflammatory signaling and enhancing hMSC viability under inflammatory conditions
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Indeed, by promoting the transport of long-chain fatty acids into mitochondria, it reduces the availability of intracellular lipids required for sebum synthesis in sebaceous glands
Yet, numerous challenges and uncertainties remain, underscoring the importance of ongoing scientific investigation and collaboration
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