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Auranofin shows an additive effect with COJEC chemotherapy Because the antagonism observed between RSL3 and COJEC appears to be mediated by GPX4 upregulation, we decided to test COJEC in combination with a ferroptosis-inducing agent with a different MOA, the TrxR inhibitor Auranofin

however, these effects were rescued by IGF-1 lentiviral vector (Fig

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