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The IRS1 and TRS1 genes from human cytomegalovirus (HCMV) have been inserted into HSV-2 to improve protein synthesis and replication by inhibiting PKR kinase activity and autophagy, thereby facilitating robust viral protein production and survival within tumor cells (81)

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[DOI] [PubMed] [Google Scholar] 78.Freiherr J., Hallschmid M., Frey W.H., Brnner Y.F., Chapman C.D., Hlscher C., Craft S., De Felice F.G., Benedict C

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