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Unlike synthetic drugs, GLP-1 natural activators work in harmony with your bodys processes to promote long-term wellness

Eli Lilly looks to be the closest, with positive results from phase 3 clinical trials of its once-a-day pill orforglipron emerging in April, June and August

Together, the results add to the evidence supporting tirzepatides effects and safety, says Susan Yanovski, a physician and nutrition specialist at the National Institute of Diabetes and Digestive and Kidney Diseases in Bethesda, Md

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GLP-1 RAs not only ameliorate insulin resistance and microvascular injury [84], which are significant determinants of depression in T2DM, but also enhance dopamine metabolism and stimulate growth factor signaling pathways, suggesting potential neuroprotective functions [85,86]

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