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[42] [43] El glutatin es un componente intracelular fuertemente regulado y limitado en su produccin debido a la inhibicin de retroalimentacin negativa de su propia sntesis a travs de la enzima gamma-sintetasa glutamilcistena

However, when resistance does occur, such as in Candida albicans or Aspergillus , it is typically associated with mutations in the ergosterol biosynthesis pathway, particularly in genes such as ERG2 , ERG3 , ERG5 and ERG11 ( Jensen et al., 2015)

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Paradoxically, while iron toxicity in PD is linked to dysfunctional iron metabolism, intragastric delivery of iron carbonyl boosts the biosynthesis of iron-sulfur clusters and elevates aconitase 1 activity, which is crucial for mitochondrial function and iron homeostasis, thereby preventing ferroptosis in vivo (188)

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