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The STEP clinical trials of semaglutide showed average weight reductions of roughly 12 to 15 percent of starting body weight over 68 weeks, while the SURMOUNT trials of tirzepatide showed slightly greater average weight loss, with reductions of roughly 18 to 22 percent of starting body weight at the highest doses

doi: 10.3389/fnagi.2023.1129095

Another side effect to keep an eye on is digestive issues , including constipation and diarrhea

What if I am not losing weight after 4 weeks on semaglutide

Obstructive sleep apnea occurs when a persons upper airway becomes blocked, which can lead to pauses in breathing during sleep

3b, Supplementary Fig