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Conclusively, research on GLP-1R and its agonists marks a promising direction in metabolic disease therapy, extending their potential beyond glucose regulation and offering hope for more comprehensive approaches in addressing metabolic diseases

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This high prevalence lends further support to the potential immediate impacts of GLP-1 RAs 37 , possibly offering protection and aiding in recovery from acute insults

There are also motility alterations, such as diarrhea explained by the rapid colonic transit, as GLP1 activates intrinsic afferent neurons containing calcitonin gene-related peptide that favors the frequency of peristaltic contractions (158) or constipation due to mechanisms dependent on nitric oxide and AMPc/PKA that reduces colon contractility (159)

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism