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Couture Med Spa reports a similar pattern among its own tirzepatide and semaglutide patients, listing mild nausea or upset stomach, temporary irritation at the injection site, fatigue or headaches, and changes in appetite, and adds that most side effects fade as the body adjusts to treatment (couturemedspa.com)
It is currently advancing through Phase 3 clinical trials for obesity treatment
Severe or non-stop vomiting, or you can't keep fluids down (dehydration) Severe stomach pain, especially if it spreads to your back (possible pancreatitis) Upper-right belly pain, fever, or yellowing skin/eyes (gallbladder) Signs of an allergic reaction swelling, trouble breathing, a spreading rash These are class-wide GLP-1 warnings
While it is effective, its use requires careful monitoring for side effects and is most beneficial when combined with lifestyle changes like diet and exercise
However, whether these effects are mediated through GLP-1 or GIP pathways remains unclear