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Stress management: cortisol vs GLP-1 Chronic stress: High cortisol Insulin resistance Intestinal inflammation Decreased GLP-1 Proven stress-reduction techniques: Heart coherence: 5 min, 3 times/day (365 method) Meditation: 10-20 min/day Yoga: 2-3 times/week Nature walk: 20-30 min/day Deep breathing: 4-7-8 (inhale for 4 seconds, hold for 7 seconds, exhale for 8 seconds) Result: 30% reduction in cortisol = improved GLP-1 + easier weight loss Dietary supplements: a targeted boost While diet and lifestyle are the foundation, some supplements enhance GLP-1

Take home message Eli Lilly reported on 21 May 2026 that retatrutide produced an average weight loss of up to 30.3% in its Phase 3 TRIUMPH-1 trial, the largest figure reported so far for a weight-loss injection

Early comparisons of retatrutide vs tirzepatide suggest this triple action may deliver greater weight loss results, though direct head-to-head trials have not been completed

Anti-inflammatory effects of tirzepatide: a systematic review and meta-analysis

Because of its appetite-suppressing effects, its sometimes used for its weight-loss benefits