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These deposits range from tiny grains to golf ball-sized stones

Additionally, environmental factors such as iodine excess or deficiency, smoking, stress, exposure to chemicals, medications (e.g., amiodarone, interferon-), and some viral/bacterial infections can alter gene expression patterns through epigenetic mechanisms and trigger autoimmune processes

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In particular, statins can modulate the abundance of gut microbiota producing SCFAs, SBAs, TMAO, and LPS, which in turn affect the AMPK-SREBP, FXR, PXR, FFAR2, and TLR4-Myd88 signaling pathways

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