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Observational studies A large number of cross-sectional and prospective cohort studies have associated elevated blood homocysteine concentrations with measures of poor cognitive scores and increased risk of dementia, including Alzheimer's disease (reviewed in 67, 69)

Severe GI adverse reactions have also been reported postmarketing with GLP-1 receptor agonists

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Temporary blindness may last as long as 2-3 weeks

If this does occur, the time this sensation lasts varies by patient, with some people feeling numb for a few hours and others feeling numb for several weeks