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A comprehensive analysis of the known effects of GLP-1 and GLP-1RAs on cognitive, cellular, and molecular changes in NDD in preclinical and clinical studies have shown that both natural GLP-1 and its analogues, GLP-1RAs (dulaglutide, exenatide, liraglutide, lixisenatide, semaglutide, and tirzepatide) improve cognitive and motor functions

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These numbers established tirzepatide as the most effective weight loss peptide available at the time of approval

Cost and insurance coverage: Cost is one of the most significant barriers to continuing to use Ozempic and other weight loss medications