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Furthermore, OS induces relaxation, modulating the opening of four potassium channels present in arterial smooth muscle cells: voltage-dependent K + channels (KV), Ca 2+ -activated K + channels (KCa), rectifying K + channels (Kir), and ATP-sensitive K + channels (KATP) (138)

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LPO products can abrogate the function of PI3K specifically by caused conformational change that leads to the removal of the catalytic subunit or by competition with the regulatory subunit [111,112,113]