The structural changes lower its affinity for IGF binding proteins and stretch its half-life to roughly 20-30 hours
PLoS ONE, 3(12), e4015
Lower concentrations of GABA have been observed in major depression and post-traumatic stress disorder in the brain, and a region of the brain known as the insular cortex that is associated with emotional response.* Lower insula levels of GABA are associated with a significantly higher trait and state anxiety.* GABA, as an inhibitory neurotransmitter, is one of the mediators responsible for reducing the response to fear or anxiety-provoking stimuli.*
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Ito et al., 2023) (this may be particularly relevant for the destabilization of myelin), synaptic dysfunction (Tu et al., 2014) (this includes impairment of signaling at the axo-myelinic synapse, crucial for survival of the myelinated axon
