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Patients on maintenance doses retained 70 to 85% of their peak weight loss at two years, compared to 40 to 60% retention for those who stopped completely but implemented lifestyle changes, and less than 30% for those who stopped without significant lifestyle modification

Other notable health improvements included lower incidence of claims for pneumonia, inflammatory bowel disease, osteoporosis, and alcohol and substance use disorders compared to a precisely matched control group

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes (SUSTAIN 6)

In-use time limit exceeded once opened, multi-dose GLP-1 pens must be discarded after the manufacturer's specified duration (typically 14 days to 6 weeks), even if doses remain

Two early-phase human studies of the DAC form showed it raises GH and IGF-1 for days after injection while preserving pulsatile GH secretion