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The median weight loss across published trials is 4 to 6 pounds, and most of that occurs in the first 12 weeks with minimal further loss afterward

Frontiers in nutrition, 2, 23

Journal reference: Prof Filip K & Julio R et al., (2023) Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial

Georg Thieme Verlag Stuttgart New York

"That doesn't mean the medications are necessarily causing these symptoms, but it could suggest that reports of menstrual changes and body temperature fluctuations are worth studying more systematically." Researchers Hope to Expand Beyond Reddit The team hopes the findings encourage scientists and healthcare providers to pay closer attention to the kinds of side effects patients are discussing online