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To evaluate the impact of the inter-individual variability (IIV) in the predicted PK and in the PK/PD time course, three levels of IIV were considered (with 15%, 30%, and 45% coefficient of variation [CV])

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Thereafter, the compound motor action potential (CMAP) was recorded from the same pair of electrodes after stimulating the first and second electrodes (a repetition of 1 Hz and a stimulus duration of 0.05 ms)

10.1073/pnas.0608175103 127 Cuevas-VelazquezC