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The glucagon-like peptide-1 receptor agonists (GLP-1 RAs), and now next-generation multi-agonists that include GLP-1 activity, are producing average weight reductions far larger than previously expected from drugs, reshaping clinical practice and how clinicians and patients think about obesity treatment

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Pulsatile dosing: Some experiment with dose cycling (e.g., one month on, one month off) to minimize tolerance development

The future directions and challenges of new small-molecule GLP-1R agonists, such as danuglipron, are multifaceted

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