In Kupffer cells (liver macrophages) during liver IR, its shown that NLRP3-driven IL-1 release contributes to hepatocyte injury and neutrophil recruitment (24)
doi: 10.1016/S0140-6736(15)60327-0 Summary Keywords food intake, melanocortin (MC), melanocortin-3 receptor, melanocortin-4 receptor, melanocortin-4 receptor agonist, metabolism, obesity, weight loss Citation Prindle CR, Bennett TL, Rajewski BH, Kelley KJ, Impastato AC, Potterfield R, Marks DL and Delev JY (2026) The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives
Muscle is metabolically active tissue that burns calories even at rest, helping to sustain weight loss over time
De Silva NL, et al
Recent Trends Advancements of GLP-1 Receptor Agonists The landscape of obesity treatment has evolved significantly due to the effectiveness of GLP-1 receptor agonists semaglutide (Wegovy) and tirzepatide (Mounjaro) in reducing hunger and facilitating substantial weight loss
they need certainty that their treatment continues