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Measures of Disease Frequency of 2050 cases per 100,000 persons Female-to-male ratio of 8:1 Onset usually at 2040 years of age In children, the majority of cases occur after 11 years of age

A post hoc analysis in Japan indicated that the combination of SGLT2i and GLP-1RA was superior to monotherapy in improving liver function parameters (ALT, AST), hepatic steatosis index (HSI), and fibrosis index (FIB-4), suggesting complementary mechanisms between the two

Fetal metabolism uses sulfation pathways that become saturated, shunting more drug to the toxic pathway

Branco, A.C.C.C., Yoshikawa, F.S.Y., Pietrobon, A.J., Sato, M.N

doi: 10.1038/srep00266 87 PruettSBObiriNKielJL

Viral infections such as norovirus and rotavirus are more common causes, but bacterial infections can cause it too