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In addition, it supports the transport of intermediate toxins out of the mitochondria, preventing their accumulation

That structural feature is significant: proline residues resist proteolytic cleavage, making the peptide unusually stable in gastric conditions relative to most short peptides [1]

As ATP production becomes more efficient and less toxic, patients often report a gradual lifting of the heavy, leaden feeling in their limbs, a reduction in the severity of post-exertional crashes, and an improvement in their overall stamina and cognitive clarity

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Moreover, the concept of proteostasis resilience, the capacity of cells and tissues to preserve proteome integrity under sustained stress, is emerging as a powerful unifying lens to understand disease vulnerability, progression, and therapeutic responsiveness