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Mechanistic Incretin/Glucagon Research: Used to isolate the contributions of each receptor in appetite regulation, insulin sensitivity, lipid handling, and whole-body energy regulation
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For tirzepatide versus semaglutide, contrary to the primary endpoint in the head-to-head comparison, there was some supporting evidence for tirzepatide to have a modest benefit, although the 95% CI overlapped the null (HR 0.91, 95% CI 0.81 to 1.01) (Fig
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52 Therefore, the potential benefits of dulaglutide for MASLD may be promising
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