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3, 4 In a crossover pharmacokinetic study of PROIN ER in fed and fasted dogs, post-prandial drug administration was associated with approximately a 23% increase in the maximum plasma concentration (Cmax), but the area under the concentration vs time curve to the last quantifiable concentration (AUClast) was similar in both fed and fasted states

The norleucine-4 and D-phenylalanine-7 modifications are verified through sequence analysis on every production batch

Antoniou et al

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