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There is no research showing that taking well over the recommended daily or weekly amount of B12 can be unsafe or detrimental to your health, and an official upper tolerable intake level has yet to be established

Fifty percent of the steady-state concentration is reached after one half-life, 75% after two half-lives, and over 90% after four half-lives

As with any supplement, individuals with medical conditions or those taking prescription medications should consult a healthcare practitioner before use.

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Lyophilized powder is typically favoured in laboratory settings because it allows precise reconstitution, flexible concentration ranges, and greater control over experimental variables

A few commenters also expressed concern that the proposed attestation that the hospital has provided all necessary information available to the hospital for the public to be able to derive the dollar amount risks ensnaring hospitals and health systems in a trap: since hospitals are unable to provide this detailed information, they cannot meet the new requirements of the attestation