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In clinical research, participants taking the highest dose of Retatrutide lost an average of 24.2% of their body weight over 48 weeks

doi: 10.2337/dc15-2849 117 Alhadj AliMLiuYFArifSTatovicDShariffHGibsonVBet al

At higher doses, the glucagon receptor activation may actually help preserve lean mass through increased protein turnover and growth hormone modulation, but the data on this is still emerging

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