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According to the National Institute on Alcohol Abuse and Alcoholism, in 2021 just 5% of the 29 million Americans with alcohol use disorder took medication for the condition

doi:10.1017/S1461145711000617, PMID: 21733244 Gawryluk JW, Wang JF, Andreazza AC, Shao L, Young LT (2011) Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders

Their findings increasingly support this idea, suggesting that effective therapy might require engaging both systems differently

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This detailed interaction profile highlights the dimers superiority over the monomer, suggesting that dimerization could be a promising strategy for developing more potent GSTP1 inhibitors, especially for applications targeting chemoresistant cancers