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The Phase 2 trial enrolled participants with obesity and evaluated multiple dose levels over 48 weeks: 1 mg dose: 8.7% average body weight reduction 4 mg dose (escalated from 2 mg): 17.1% average body weight reduction 8 mg dose (escalated from 2 mg): 22.8% average body weight reduction 12 mg dose (escalated from 2 mg): 24.2% average body weight reduction Placebo: 2.1% average body weight reduction Those Phase 2 numbers were striking enough

Depending on the medication and how well you tolerate it, they may increase your dose each week or every four weeks

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

While causation has not been definitively established, immune modulation through GLP-1 receptor pathways may contribute

If the effects are blunted, can I just take a higher dose of psychedelics

They have demonstrated a consistent reduction in the risk of mortality in patients with T2D and established heart disease, and in patients with HF with reduced ejection fraction (HFrEF)