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It should be avoided by: Pregnant or breastfeeding women People with personal or family history of medullary thyroid carcinoma People with Multiple Endocrine Neoplasia syndrome type 2 Those with a history of pancreatitis Patients with severe gastrointestinal disease Individuals with a history of suicidal thoughts or behaviors People with diabetic retinopathy complications Long-Term Safety Considerations The medical community continues to study the long-term safety of semaglutide

Retatrutide follows a once-weekly injection schedule, starting at 1-2mg and titrating up to 12mg over several months

Resolved October 2, 2024

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The freeze-thaw cycle can fracture the peptides delicate structure, denaturing it and reducing its efficacy

Participants were started on lower doses typically 1 mg or 2 mg subcutaneously once weekly and gradually titrated upward over multiple weeks to maintenance doses of 4 mg, 8 mg, or 12 mg administered subcutaneously once weekly