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Cookie-cutter protocols ignoring these variables produce suboptimal outcomes, while thoughtful individualization maximizes benefits within each patient's physiologic capacity

These effects can be reversed by introducing wild-type ChaC1 but not by a catalytically inactive mutant, emphasizing the importance of its enzymatic function

doi: 10.1002/14651858.CD003538.PUB2 247 NortonRLHoffmannPR

[1] Note the comparator carefully: it was liraglutide, not tirzepatide

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However, individuals with kidney disease, heart failure, or uncontrolled hypertension should consult their physician before exceeding 2,300mg sodium daily