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SGLT-2i pairs, GLP-1RA therapy was associated with higher risks of HSV (HR = 1.387, 95% CI = 1.2491.539) and HZ (HR = 1.294, 95% CI = 1.2031.392) compared to DPP-4i and HSV (HR = 1.277, 95% CI = 1.1321.442) and HZ (HR = 1.18, 95% CI = 1.0851.284) compared to SGLT-2i

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Fair quality of methodology was considered in studies that enrolled only male subjects (population category) [14, 22, 25, 26, 28] or when blood sampling did not coincide with a steady state of an investigated drug [13,14,15,16,17, 19, 24]

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