From a regulatory perspective, exosome-based products represent a new class of biologic therapy, and navigating the approval pathways will require robust data on their biodistribution, potential immunogenicity, and long-term safety, establishing clear guidelines that are still under development
It makes an excellent chicken broth for cooking, too
Characteristics and preparation of solid lipid nanoparticles and nanostructured lipid carriers
doi: 10.1177/0748233715571152
Voloboueva LA, Emery JF, Sun X, Giffard RG
This scheme proposes the following steps: (i) a one electron reduction of lucigenin (L) under the influence of cytochrome P450-reductase and NADPH to generate a radical species (LH + ), (ii) a reaction between the latter and ground state oxygen to produce O 2 - and recycle the lucigenin back to its native state (L), (iii) and finally a reaction between LH + and O 2 - , generated as a result of the redox cycling of lucigenin, to produce a dioxetane that, in turn, decomposes with the generation of chemiluminescence (Fig
