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In addition, the translocation of commensal microbes to extraintestinal sites has been reported to promote immune profiles characteristic of certain autoimmune diseases (ADs) (Fine et al

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Biochemically, ferroptosis is indicated by the inhibition of cystine/glutamate antiporter (System Xc ), the depletion of glutathione (GSH), decreased activity of glutathione peroxidase 4 (GPX4), accumulation of lipid peroxides (LOOH), and a decline in mitochondrial membrane potential (Mao et al., 2021

Of note, the decrease in homoeostatic capacity of astrocytes seems to be the prevailing mechanism across various neuropathologies

doi: 10.1002/jnr.21996