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Specifically, the BA metabolites 3-oxolithocholic acid (3-oxoLCA) and iso-lithocholic acid (isoLCA) impede Th17 cell differentiation by directly binding to retinoic acid receptor-related orphan receptor gamma t (RORt), a key transcriptional promoter of Th17 cells ( Figure 2 )

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Xue B et al

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In addition, testosterone levels were reduced by 82%, and LH-stimulated testosterone production was decreased (67)