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The findings, presented at the American College of Cardiology's (ACC) Annual Scientific Session and Expo in Chicago, and simultaneously published in the New England Journal of Medicine, mark a major advancement in cardiometabolic treatment

Cholesterol extraction from pancreatic beta cells has previously been shown to disrupt the internalisation, clustering and cAMP responses of the glucagon-like peptide-1 receptor (GLP-1R), a class B1 GPCR with key roles in the control of blood glucose levels via the potentiation of insulin secretion in beta cells and weight reduction via the modulation of brain appetite control centres

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Avanti C, Saluja V, Van Streun ELP, Frijlink HW, Hinrichs WLJ

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Peign et al., 2022)