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L-Lysine is able to cross the blood-brain barrier and reach a part of the brain where it is metabolised into -aminoadipic acid, which can interact with a number of neuroreceptors (1)

doi: 10.2337/figshare.14272955.v1 86 AlbaMYeeJFrustaciMESamtaniMNFleckP

Ethics approval and consent to participate This study was reviewed by the Natural and Non-prescription Health Products Directorate (NNHPD), Health Canada and a research ethics board, which granted ethics approval in December, 2014