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The cost savings could make these drugs accessible to patients who simply couldnt afford them before
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PubMed, doi:10.1021/acs.est.5b04059
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[DOI] [PMC free article] [PubMed] [Google Scholar] 446.Yang C, Merlin D
Meanwhile, it inhibits the phosphorylation of MAPK1 (ERK1/2) to block the proliferation of PASMCs, downregulates NOX4 to reduce ROS production for alleviating oxidative stress, and improves right ventricular fibrosis and energy metabolism by regulating the TGF-1/Bcl-2-Bax axis (Luo et al., 2021
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