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The main mechanism of ferroptosis Inhibiting the cysteine-glutamate transporter system Xc can induce ferroptosis System Xc is a sodium independent antiporter that export intracellular glutamate and import extracellular cystine across the membrane in a ratio of 1:1 to synthesize glutathione in cells [19]

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Ahmed S, Ghazarian MP, Cabanillas ME, Zafereo ME , Williams MD, Vu T, Schomer DF, Debnam JM

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