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According to NICE guideline NG28, GLP-1 receptor agonists may be considered for type 2 diabetes when metformin is contraindicated or not tolerated, or in combination with other diabetes medications

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For patients with ASCVD or risk factors for ASCVD, a GLP-1RA with proven benefit on CV outcomes is the preferred choice of add-on therapy, or an SGLT-2 inhibitor with proven CVD benefit if the estimated glomerular filtration rate (eGFR) is considered adequate (30 to 60 ml/min 1.73 m 2 )

If you feel significantly more side effects than usual, it may be a sign that your body prefers a full seven-day interval

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