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The oncometabolite, 2-hydroxyglutarate (2-HG), also couples the NADP + /NADPH to epigenetic modification, including histone and DNA demethylases, in tumorigenesis

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(1) Synthesis of the head group: In mammals, the conserved head group precursor for CoQ 10 is 4-hydroxybenzoate (4-HB), which is derived from tyrosine