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As shown for GLP-1RAs, the discovery of pleiotropic effects can effectively extend the lifespan and markets of drugs by facilitating repurposing

For example, glucose deprivation induces rapid NADPH depletion, promoting ferroptosis-mediated oxidative stress and cell death [16]

Finally, we simulated the PfGrx C88S -dependent reduction kinetics for roGFP2(S 2 ) using the three alternative mechanisms from Fig

M.LinS.FangJ.ZengZ.et al (2018)

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