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But, it shows we need to be careful with supplements during treatment

This is a critically important distinction that cannot be overlooked

7 Clinical outcomes of pharmacotherapy To date, numerous clinical studies including double- or single-blinded randomized clinical trials and split-face studies have been conducted to assess the therapeutic effect of various topical conventional and novel formulations in melasma management as summarized in Table 3

If you are taking folic acid, your doctor should monitor your B12 levels regularly