Examples are natural killer (NK) and T-cells
The strategy was, therefore, to identify GLP-1 mimetic drugs with a molecular structure close enough to native GLP-1 to stimulate the GLP-1 receptor, but with alterations that enabled prolonged activity by, in particular, possessing resistance to breakdown by DPP-4 (Meier, 2012)
The challenge is that fiber is found in carbohydrate-containing foods
This leads to rapid bacterial growth and peptide degradation
How well the drug is working for you: Some people are non-responders to semaglutide, meaning that the drug doesnt adequately lower their body weight or blood sugar levels
consequently, this may represent a potential concern during GLP-1 RA-based obesity interventions