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At 24 months follow-up, HbA 1c increased in both groups to above baseline [80], while weight loss (3.9 kg) was maintained in both groups [81]

Pc: Pyramidal cells

The gastrointestinal effects result primarily from delayed gastric emptying and altered gut motility

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The symptoms most commonly observed in the study were high-spiking fever, unusual lethargy over several days (asthenia), digestive signs including severe abdominal pain, vomiting or diarrhea, swollen lymph nodes (adenopathy) and skin rash

That being said, sleep optimization works best as part of a broader lifestyle approach that includes diet and exercise, not as a standalone strategy