One critical point in understanding at the molecular level the toxicity of thiol-binding mineral elements such as As, Cd, Hg and Pb is that in ex vivo , in vitro assays toxicity occurs at micromolar concentration
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Ewa [13] and Kim [14] reported that coenzyme Q10 (CoQ10) and deferoxamine (DFX) promoted fat graft survival, respectively
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Alpha-lipoic acid suppresses osteoclastogenesis despite increasing the receptor activator of nuclear factor kappaB ligand/osteoprotegerin ratio in human bone marrow stromal cells
As will be discussed, one mechanism which may connect thiol-metal binding to oxidative stress-mediated toxicity is specific of Hg, the cysteinyl-glycine bound form of which is able to deplete glutathione reservoirs by a catalytic process [34]
