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While Epithalon did not significantly influence food consumption, body weight, or mean life span, it did slow down the age-related switching-off of estrous function, decreased the frequency of chromosome aberrations in bone marrow cells, and significantly increased the maximum life span (by 12.3%) and the life span of the last 10% of survivors (by 13.3%)
Sanchez-Lozada, L
Remarkable differences in nuclear factor kappa-B (NF-B) activity, cytokine production, leukocyte migration that involved in the inflammatory response, and other biological targets (such as NCOA4, glutamate-cysteine ligase catalytic subunit and Aldo-keto reductase family 1-member C1) are also observed when compared to those in controls
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J Genet Genomics 48:369383 Florens L, Carozza MJ, Swanson SK, Fournier M, Coleman MK, Workman JL, Washburn MP (2006) Analyzing chromatin remodeling complexes using shotgun proteomics and normalized spectral abundance factors