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Modulation of CPT-1 may affect energy metabolism and food intake, and research is ongoing into the effects of both stimulation and inhibition of CPT-1 and in relation to obesity management [74]

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87 One study followed 3299 patients with primary adrenocortical insufficiency for 40 years, determining that the standardized incidence ratio (SIR) for melanoma skin cancer was numerically less than expected (0.7