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Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the gold standard for quantifying dihexa in plasma, with a lower limit of quantification typically around 15 ng/mL depending on sample preparation and ionization efficiency

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Enhanced Molecular Target Coverage Combined treatment protocols demonstrate additive effects on multiple enzymatic pathways, including matrix metalloproteinase expression and activity

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Because a reduction in oxidative stress may help maintain cognitive status and/or prevent deterioration, the effects of vitamin E supplementation have been assessed in a few intervention studies