Children's requirements are lower and increase with age: infants aged 0-6 months have a safe intake of about 0.3 g daily, those aged 712 months need 0.4 g daily, children aged 13 years require 0.5 g, those aged 46 years need 0.8 g, and children aged 710 years should receive 1.0 g daily
Adipokines released by adipocytes cause insulin resistance which causes ovarian androgen production as well as alteration in lipid homeostasis (40)
Rarely, bicarbonate loss may approach 10 mEq/L
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